Engineering of Brome mosaic virus for biomedical applications
نویسندگان
چکیده
منابع مشابه
Engineering of Brome mosaic virus for biomedical applications.
Viral nanoparticles (VNPs) are becoming versatile tools in platform technology development. Their well-defined structures as well as their programmability through chemical and genetic modification allow VNPs to be engineered for potential imaging and therapeutic applications. In this article, we report the application of a variety of bioconjugation chemistries to the plant VNP Brome mosaic viru...
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The genome of brome mosaic virus (BMV) is divided among messenger polarity RNA1, RNA2, and RNA3 (3.2, 2.9, and 2.1 kilobases, respectively). cis-Acting sequences required for BMV RNA amplification were investigated with RNA3. By using expressible cDNA clones, deletions were constructed throughout RNA3 and tested in barley protoplasts coinoculated with RNA1 and RNA2. In contrast to requirements ...
متن کاملOptical nano-constructs composed of genome-depleted brome mosaic virus doped with a near infrared chromophore for potential biomedical applications.
We have engineered an optical nanoconstruct composed of genome-depleted brome mosaic virus doped with indocyanine green (ICG), an FDA-approved near-infrared (NIR) chromophore. Constructs are highly monodispersed with standard deviation of ±3.8 nm from a mean diameter of 24.3 nm. They are physically stable and exhibit a high degree of optical stability at physiological temperature (37 °C). Using...
متن کاملLongidorus breviannulatus as a Vector for Brome Mosaic Virus.
Longidorus breviannulatus N o r t o n & Hoffmann, 1975 was described from corn in Iowa. Brome mosaic virus (BMV) was initially isolated in the Great Plains area of the United States from perennial brome grass, Bromus inermis. Infrequent localized outbreaks of BMV in barley were believed to result from mechanical inoculation by farm machinery moving across infected brome grass and into barley fi...
متن کاملTubule-forming capacity of the movement proteins of alfalfa mosaic virus and brome mosaic virus.
The structural phenotype of the movement proteins (MPs) of two representatives of the Bromoviridae, alfalfa mosaic virus (AMV) and brome mosaic virus (BMV), was studied in protoplasts. Immunofluorescence microscopy showed that the MPs of these viruses, for which there has been no evidence of a tubule-guided mechanism, assemble into long tubular structures at the surface of the infected protopla...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2012
ISSN: 2046-2069
DOI: 10.1039/c2ra01376b